Non-partisan coalition of industry, academic, civil-society, and research leaders working to accelerate scientific discovery through AI and emerging technologies

Policy research on regulatory and institutional reform to enable abundance

Canadian think tank on industrial strategy and economic competitiveness

Promotes open research practices; builds and operates the Open Science Framework (OSF)

DeSci ecosystem map, community hub, and podcast

Science policy research and advocacy; founded by Manhattan Project scientists in 1945

Improving research quality, reproducibility, and science funding effectiveness

DC think tank on science funding, immigration, and innovation policy

Epistemics research; studying how intellectual communities develop knowledge

Global deep-tech organization translating advances in nanotechnology, bionanotechnology, and biotechnology into scalable industrial and healthcare solutions; operations in the US, Brazil, and Portugal

FAS · IFP · J-PAL partnership

Philanthropic fund supporting science and technology policy

Advancing open, blockchain-based scientific infrastructure

Irish think tank on economic growth, regulatory reform, and progress

Improving how philanthropic capital is deployed in science

Metascience research, policy and practice

Building intellectual foundations for a philosophy of technological progress

Independent UK research & policy studio on science system reform

Coalition of 25+ metascience orgs; launched July 2025

Platform for citizen science and open collaboration; envisions deinstitutionalized science powered by online communities and AI

DeSci space mapping & podcast

UK government body overseeing seven research councils; ~£8B annual budget

US government health ARPA

UK's DARPA-like R&D agency

Germany's Federal Agency for Breakthrough Innovation (2019); operates outside standard procurement with empowered program managers and portfolio-level accountability; model for the Franco-German breakthrough innovation report (2026)

Independent research org funding ambitious science and building AI for researchers

Builds AI agents to accelerate scientific discovery

Private ARPA-model research organization; runs ambitious scientific programmes

Independent Bay Area biomedical research institute; unrestricted long-term funding

Open-format biological research; continuous publishing without traditional journals

Platform for tokenizing scientific IP and funding research through decentralized mechanisms

Independent research institute outside academia; focus on longevity biology

Advancing nanotechnology, longevity, AI safety, and beneficial futures since 1986

Philanthropic fund supporting science and technology policy

DeSci-focused investment fund

DKK 115B Danish philanthropic foundation; major funder of life sciences and global health

Formerly Open Philanthropy (rebranded Nov 2025); major EA-aligned funder across global health, biosecurity, AI safety, and science

Improving how philanthropic capital is deployed in science

Eric Schmidt philanthropy funding cross-disciplinary science and emerging research talent

UK government body overseeing seven research councils; ~£8B annual budget

Tyler Cowen's small grants for individuals and ideas with potential for large-scale impact

Funds open source and public goods through Ethereum and quadratic voting

£37B endowment; Europe's largest private science funder

$10B+ committed to AI + biology; potential largest private biomedical funder

EU's frontier research funding agency; €16B budget (2021–27)

Major funder of science, technology, and economic research; supports living evidence synthesis and replication

FRO incubator

New mammalian models for preclinical research

Disordered proteins as drug targets

Full-stack brain architecture mapping

Open-source tools for novel microorganisms

High-throughput proteomics & open science

Mapping the pharmom

Lean proof assistant scalability

Ultrasonic whole-brain computer interface

Ocean-based CDR modeling & data

Mapping synaptic connections in living animals; ARIA-backed

Ecological monitoring and forecasting infrastructure; ARIA-backed

Biotech & health innovation through fungi

Fund, develop & govern tokenized scientific IP

Backfilling womxn's non-reproductive health data

Funding women's health research

Brain health & neurodegeneration

Advancing cryopreservation research

Eradicating rare diseases

Fixing hair loss for good

Curing Long COVID together

Accelerating peptide research

Psychedelics & mental health research

Advancing quantum biology research

Health data & scientific discovery ecosystem

Accelerating spine care & research

Lab to life in half the time

Synthetic biology research funding

Tackling aging with global community

Open-source atlas of cell surface proteins for targeted drug delivery

Longevity research platform using AI and blockchain for health data aggregation

Blockchain platform for biospecimen data sharing between biobanks and researchers

DeSci-enabled biotech for neuropsychiatric drug discovery

Open-access digital publishing platform by Radial; community-driven evaluation, no pre-publication peer review, DOI-indexed

AI-powered tool for verifying scientific claims in papers

Decentralized platform for open scientific publishing

Builds decentralized publishing infrastructure; created the DeSci Nodes protocol

Blockchain-based scientific publishing and IP management

Multi-discipline preprint server operated by MDPI

Decentralized scientific publishing platform

Open science platform for sharing and evaluating research; founded by Brian Armstrong

Tokenizes scientific publications and IP as NFTs

New peer-reviewed journal; edited by Gemma Derrick, Serge Horbach, Bart Penders & Tony Ross-Hellauer. 2026.

Global DeSci community, events, and ecosystem mapping

International network connecting DeSci communities worldwide

DeSci community for Latin America

UK-based DeSci community

X community connecting DeSci organizations and builders

San Francisco Declaration on Research Assessment; 26,000+ signatories across 171 countries

Coalition for Advancing Research Assessment; 800+ institutional signatories committed to reforming research evaluation

Cross-institutional network promoting open and reproducible research in the UK

Builds systems for computational reproducibility and independent robustness checks of published findings

Produces gold-standard systematic reviews of clinical and health evidence; global network of 13,000+ researchers

Blockchain health data sovereignty platform connecting patients and researchers

AI and blockchain platform for clinical data management in hospitals

Decentralized protocol for funding rare and neglected disease research

Patient-controlled health data sharing platform

Web3 platform rewarding users for sharing health and wellness data

DAO incubator