Metascience

This resource maps the metascience ecosystem: the organizations, individuals, ideas, and infrastructure shaping how science is funded, organized, and practiced, including alternative models such as focused research organizations, new funding mechanisms, and decentralized science (DeSci). It covers 200+ organizations and individuals, a growing primer library, trackers that follow live developments, The research system series, and a newsletter on Substack and LinkedIn. It is maintained by David Hilmer Rex, a researcher working on how to diversify the institutions and funding mechanisms of the research system (work with me). For contact, send me an email or dm me.

This resource builds on: UltraRareBio's DeSci mapping, Vincent Weisser's DeSci and Metascience resources, Overedge Catalog by Samuel Arbesman, and ResearchHub's DeSci Ecosystem Overview.

Metascience here follows Nielsen and Qiu's definition: exploration of new social processes for science.

Recently Added

    News

    → News archive: 2024 and earlier, and DeSci news from 2025

    Media

    Podcasts

    • Idea Machines — Ben Reinhardt's long-form interviews on how breakthroughs happen and how to create the conditions for more of them.
    • Macroscience — Caleb Watney and Tim Hwang on science policy, the mechanics of innovation, and the institutions that govern research.
    • Proof of DeSci — interviews across the decentralized science ecosystem: funding models, DAOs, and emerging infrastructure.
    • The DeSci Podcast — conversations with builders, researchers, and funders at the intersection of science and web3.
    • Foresight Institute talks — seminars on nanotechnology, longevity, computation, and the long-run future of science and technology.

    Newsletters

    • Metascience — this newsletter: new entries, primers, and developments across the ecosystem. Also on LinkedIn.
    • DeSci Weekly — weekly roundup of news, funding, and commentary from the decentralized science space.
    • FreakTakes — Eric Gilliam on the history and future of innovative research, with focus on biotech and institutional design.
    • Works in Progress — long-form essays on how things get better and what holds progress back, across science, technology, and policy.

    → Talks, conferences, and more

    Organizations

    ARIA

    UK's Advanced Research and Invention Agency; programme-manager-driven, DARPA-inspired

    Center for Open Science

    Infrastructure, tools, and incentives for open and reproducible research

    FutureHouse

    Building AI agents to accelerate scientific discovery, including Robin (end-to-end research agent)

    Astera Institute

    Philanthropic research organization developing infrastructure for open science and breakthrough research

    Arc Institute

    Independent research institute combining basic science with long-horizon technology development

    Convergent Research

    Venture studio originating Focused Research Organizations; builds the Gap Map of R&D bottlenecks

    Institute for Progress

    Science and technology policy think tank; works on immigration, FDA reform, and new funding models

    VitaDAO

    Decentralized longevity research organization; funds early-stage research through IP-NFT model

    → Full organizations directory

    Tools & Ideas

    • Roadmapping and Gap Mapping — systematic methods for identifying where scientific infrastructure is missing and where a targeted intervention could unlock progress across a field.
    • Alternative Funding Mechanisms — lotteries, prizes, advance market commitments, regranting, and people-not-projects models that shift what kinds of science get funded. See the funding mechanisms primer.
    • The ARPA Model — programme-manager-driven, mission-oriented research funding pioneered by DARPA; being replicated through ARIA, ARPA-H, ARPA-E, and SPRIND.
    • Preregistration and Registered Reports — tools for separating hypothesis generation from analysis, reducing publication bias, and making research more credible before results are known.
    • Open Access and Open Infrastructure — from preprint servers and open datasets to FAIR data principles and open-source lab tools that make science more cumulative.

    → Full tools and ideas directory